The Cartwright Lab @ ASU

The Cartwright Lab is part of the Center for Evolutionary Medicine and Informatics in the Biodesign Institute at Arizona State University. We are located in Tempe, AZ USA in the Phoenix metro area. We focus on developing, implementing, and applying novel methodologies to study large, complex genomic datasets.

Our research tackles many different questions in population genetics and molecular evolution, at the interface of biology, statistics, and computer science.

  • The study of mutation patterns between human families and across species, using data from next-generation sequencing. This includes both indel and point-mutation patterns.
  • Models of frequency-dependent selection, with applications to genomic data.
  • New methods for alignment and phylogeny reconstruction that take into account the uncertainty of genomic data.
  • New methods for simulating homologous sequences that can be optimized to mimic natural datasets.

Selected Publications

  • Hufford MB et al. (in press). Genome-wide effects of domestication and improvement in landraces and modern maize. Nature Genetics.
  • Cartwright RA et al. (2012). A family-based, probabilistic method for capturing de novo mutations from high-throughput short-read sequencing data. Statistical Applications in Genetics and Molecular Biology, 11:6.
  • Conrad DF et al. (2011). Variation in genome-wide mutation rates within and between human families. Nature Genetics, 43:712-714.
  • Cartwright RA, Lartillot N, Thorne JL (2011) History Can Matter: Non-Markovian Behavior of Ancestral Lineages. Systematic Biology. doi: 10.1093/sysbio/syr012 [reprint]
  • Price N, Cartwright RA, Sabath N, Graur D, Azevedo RBR (2011) Neutral evolution of robustness in Drosophila microRNA precursors. Molecular Biology and Evolution. doi: 10.1093/molbev/msr029 [reprint]
  • The 1000 Genomes Project Consortium (2010). A map of human genome variation from population-scale sequencing. Nature, 467:1061-1073.
  • Cartwright RA (2010) Bards, poets, and cliques: Frequency-dependent selection and the evolution of language genes. Bulletin of Mathematical Biology. Dec 30. [reprint]
  • Cartwright RA (2009) Problems and solutions for estimating indel rates and length distributions. Molecular Biology and Evolution, 26:473—480. [reprint]
  • Cartwright RA (2009) Antagonism between local dispersal and self-incompatibility systems in a continuous plant population. Molecular Ecology, 18:2327—2336. [reprint]
  • Cartwright RA (2006) Logarithmic gap costs decrease alignment accuracy. BMC Bioinformatics, 7:527. [reprint]
  • Cartwright RA (2005) DNA assembly with gaps (Dawg): simulating sequence evolution. Bioinformatics, 21(Suppl. 3):iii31—iii38. [reprint]
  • For a complete publication list, see my CV.